Beathe Kiland Granerud

Norwegian version of this page Department of Nursing, Health and laboratory science

Norwegian version of this page Position

Assistant Professor

Contact

beathe.k.granerud@hiof.no

Study place

Fredrikstad

Office nr.

S-428

At present on 80 % study leave.

Academic interests

Medical microbiology (especially bacteriology), antibiotic resistance, Maldi-TOF, immunology, biomedical analysis, interdisciplinarity, ethics, communication and interaction, didactics in biomedical education.

Courses taught

Background

Bachelor in Biomedical Science (180 ECTS). University College of Bergen (now University College of Vestlandet) 2003. Bachelor thesis: "TGF beta 1's effects on the promoter region of cystatin C gene and mapping of the transcription initiation site for cystatin F mRNA".

MSc i nature- enviroment- health protection (120 ECTS). University College of Telemark (now University of South-East Norway), 2008. Master courses in medical and applied microbiology, genetics, biotechnology and bioinformatics. Master thesis: "Transferable antibiotic resistance in Eschericia coli".

Post Graduate Certificate in Education (60 ECTS). University of South-East Norway. 2018. Focus on didactics of science.

Positions held

Previously worked at Haukeland University Hospital (biomedical scientist, clinical chemistry), Telemark hospital trust (biomedical scientist, clinical chemistry), Vestfold hospital trust (biomedical scientist, clinical chemistry), Oslo University Hospital Ullevål (biomedical scientist, microbiology), University of Oslo/Oslo University Hospital Rikshospitalet (staff engineer, research and teaching medical microbiology) and Norwegian Institute of Public Health (head engineer and senior engineer, preparedness against bioterror agents and research in immunology).

Barratt-Due, Andreas; Pettersen, Kristin; Dahl, Tuva Børresdatter; Holter, Jan Cato; Grønli, Renathe Henriksen & Dyrhol-Riise, Anne Ma [Show all 20 contributors for this article] (2024). Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients. Journal of Internal Medicine. ISSN 0954-6820. doi: 10.1111/joim.13783.
Murphy, Sarah Louise Mikalsen; Halvorsen, Bente; Holter, Jan Cato; Huse, Camilla; Tveita, Anders & Trøseid, Marius [Show all 24 contributors for this article] (2023). Circulating markers of extracellular matrix remodelling in severe COVID-19 patients. Journal of Internal Medicine. ISSN 0954-6820. 294(6), p. 784–797. doi: 10.1111/joim.13725. Full text in Research Archive
Trøseid, Marius; Holter, Jan Cato; Holm, Kristian; Vestad, Beate; Sazonova, Taisiia & Granerud, Beathe Kiland [Show all 17 contributors for this article] (2023). Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19. Critical Care. ISSN 1364-8535. 27(1). doi: 10.1186/s13054-023-04356-2. Full text in Research Archive
Reyes, Luis Felipe; Murthy, Srinivas; Garcia-Gallo, Esteban; Merson, Laura; Ibáñez-Prada, Elsa D. & Rello, Jordi [Show all 51 contributors for this article] (2022). Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study. Critical Care. ISSN 1364-8535. 26(1). doi: 10.1186/s13054-022-04155-1.
Gonçalves, Bronner P.; Hall, Matthew; Jassat, Waasila; Balan, Valeria; Murthy, Srinivas & Kartsonaki, Christiana [Show all 50 contributors for this article] (2022). An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients. eLIFE. ISSN 2050-084X. 11. doi: 10.7554/eLife.80556.
Garcia-Gallo, Esteban; Merson, Laura; Kennon, Kalynn; Kelly, Sadie; Citarella, Barbara Wanjiru & Fryer, Daniel Vidali [Show all 1,775 contributors for this article] (2022). ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. Scientific Data. ISSN 2052-4463. 9(1). doi: 10.1038/s41597-022-01534-9. Full text in Research Archive
Gohli, Jostein; Brantsæter, Arne Broch; Bøifot, Kari Oline; Grub, Carola; Granerud, Beathe Kiland & Holter, Jan Cato (2022). SARS-CoV-2 in the Air Surrounding Patients during Nebulizer Therapy. Canadian Journal of Infectious Diseases and Medical Microbiology. ISSN 1712-9532. 2022. doi: 10.1155/2022/9297974. Full text in Research Archive
Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas; Søraas, Arne Vasli; Fevang, Børre & Steffensen, Anne Katrine [Show all 14 contributors for this article] (2022). Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2. Viruses. ISSN 1999-4915. 14(11). doi: 10.3390/v14112420. Full text in Research Archive Show summary
The Omicron variant of SARS-CoV-2 spreads more easily than earlier variants, possibly as a result of a higher viral load in the upper respiratory tract and oral cavity. Hence, we investigated whether the Omicron variant generates a higher viral load than that of the Delta variant in saliva and nasopharynx. Both specimens were collected from 52 Omicron and 17 Delta cases at two time points one week apart and analyzed by qRT-PCR. Viral load was measured as 10 log RNA genome copies per 1000 human cells according to the WHO reference standard. We found that Omicron cases carried a higher viral load and had more sustained viral shedding compared to the Delta cases, especially in the nasopharynx.
Furuseth, May-Tove; Kvissel, Anne Katrine; Berg, Vivian; Kjøbli, Eli; Volden, Vivi & Solli, Ann Iren [Show all 12 contributors for this article] (2022). Praksisstudienes omfang og organisering i bioingeniørutdanningen. Bioingeniøren. ISSN 0801-6828. 8, p. 24–29. Full text in Research Archive Show summary
Siden 2005 har omfang og innhold i bioingeniørutdanningen vært definert av en nasjonal rammeplan for å sikre likeverdig sluttkompetanse for alle kandidater. Fra 2019 ble en ny forskrift om nasjonale retningslinjer fastsatt. Både tidligere rammeplan og nye retningslinjer har regulert læringsutbyttene og omfang av praksis i utdanningen. I denne studien kartlegges omfang og organisering av praksisstudiene ved de ulike studieprogrammene, dette for å undersøke forskjeller og likheter og tilrettelegge for at studiestedene kan lære av hverandre. Det er innhentet data fra hvert studieprogram for omfang og organisering av veiledet intern praksis, ekstern praksis samt bacheloroppgaven. Dette ble kartlagt for alle studiestedene før og etter innføring av nye retningslinjer. Resultatene viser ulikheter i omfang og organisering av praksisstudiene og bacheloroppgaven mellom studieprogrammene i Norge og da særlig i organisering av intern praksis. De nye retningslinjene åpner samtidig opp for en videre fortolkning av praksisbegrepet og av krav til omfang og organisering av praksis. For å sikre likeverdig sluttkompetanse for ferdigutdannede, uavhengig av studiested, er det behov for i større grad enes om hva som gir tilstrekkelig omfang og god kvalitet i praksis i bioingeniørutdanningen. Denne deskriptive studien viser behov for videre forskningssamarbeid mellom studiestedene, for å utvikle en bioingeniørutdanning av best mulig kvalitet for fremtiden.
Søraas, Arne Vasli; Grødeland, Gunnveig; Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas & Fevang, Børre [Show all 32 contributors for this article] (2022). Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity. Frontiers in Immunology. ISSN 1664-3224. 13:964525, p. 1–12. doi: 10.3389/fimmu.2022.964525. Full text in Research Archive Show summary
Background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals. Methods: We measured inflammatory mediators, antibodies to the SARS-CoV-2 spike and nucleocapsid proteins, and spike peptide-induced release of interferon gamma in whole blood in 51 double-vaccinated individuals infected with Omicron, in 14 infected with Delta, and in 18 healthy controls. The median time points for the first and second samples were 7 and 14 days after symptom onset, respectively. Findings: Infection with Omicron or Delta led to a rapid and similar increase in antibodies to the receptor-binding domain (RBD) of Omicron protein and spike peptide-induced interferon gamma in whole blood. Both the Omicron- and the Delta-infected patients had a mild and transient increase in inflammatory parameters. Interpretation: The results suggest that two vaccine doses are sufficient to mount a rapid and potent immune response upon infection in healthy individuals of with the Omicron variant.
Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet & Lerum, Tøri Vigeland [Show all 28 contributors for this article] (2022). High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19. Journal of Infectious Diseases. ISSN 0022-1899. 226(12), p. 2150–2160. doi: 10.1093/infdis/jiac313. Full text in Research Archive
Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen & Yang, Kuan [Show all 28 contributors for this article] (2022). Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies. Journal of Internal Medicine. ISSN 0954-6820. 292(5), p. 816–828. doi: 10.1111/joim.13549. Full text in Research Archive
Michaelsen, Terje Einar; Emilsen, Sidsel; Sandin, Randi Helene; Granerud, Beathe Kiland; Bratlie, Diane Lynn Bryant & Ihle, Øistein [Show all 7 contributors for this article] (2017). Human secretory IgM antibodies activate human complement and offer protection at mucosal surface. Scandinavian Journal of Immunology. ISSN 0300-9475. 83(1), p. 43–50. doi: 10.1111/sji.12508. Full text in Research Archive
Lasch, Peter; Wahab, Tara; Weil, Sandra; Pályi, Bernadett; Tomaso, Herbert & Zange, Sabine [Show all 15 contributors for this article] (2015). Identification of highly pathogenic microorganisms by use of matrix-assisted laser desorption ionization-time of flight mass spectometry: results of an interlaboratory ring trial. Journal of Clinical Microbiology. ISSN 0095-1137. 53(8), p. 2632–2640. doi: 10.1128/JCM.00813-15. Full text in Research Archive
Inngjerdingen, Kari Tvete; Langerud, Beathe Kiland; Rasmussen, Henrik; Olsen, Trude Karin; Austarheim, Ingvild & Grønhaug, Tom Erik [Show all 10 contributors for this article] (2013). Pectic polysaccharides isolated from Malian medicinal plants protect against Streptococcus pneumoniae in a mouse pneumococcal infection model. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(5), p. 372–388. doi: 10.1111/sji.12047.
Michaelsen, Terje Einar; Andreasson, Ida Karine Granli; Langerud, Beathe Kiland & Caugant, Dominique A (2011). Similar Superantigen Gene Profiles and Superantigen Activity in Norwegian Isolates of Invasive and Non-Invasive Group A Streptococci. Scandinavian Journal of Immunology. ISSN 0300-9475. 74(5), p. 423–429. doi: 10.1111/j.1365-3083.2011.02594.x.

View all works in Cristin

Granerud, Beathe Kiland (2022). Slik leser vi av koronavirusets arvestoff.
Granerud, Beathe Kiland (2021). Kampen om livet - samspillet mellom mennesker og mikrober.
Bratlie, Diane Lynn Bryant; Ihle, Øistein; Langerud, Beathe Kiland & Michaelsen, Terje Einar (2011). Innate Immune Receptors-Fusion Proteins as Tools for Interaction Studies with Pectic Carbohydrates Isolated from Malian Medicinal Plants. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 361–361.
Langerud, Beathe Kiland; Inngjerdingen, Kari Tvete; Rasmussen, Henrik; Olsen, Trude Karin; Austarheim, Ingvild & Aaberge, Ingeborg Sundsvalen [Show all 9 contributors for this article] (2011). Pectic Polysaccharides Isolated from Malian Medicinal Plants can Prevent Bacteraemia and Clinical Symptoms in a Mouse Pneumococcal Infection Model. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 390–390.
Michaelsen, Terje Einar; Emilsen, S; Sandlie, I; Bratlie, Diane Lynn Bryant; Langerud, Beathe Kiland & Ihle, Øistein (2009). Human secretory IgM and serum IgM can activate complement equally well.

View all works in Cristin

Published June 12, 2018 4:16 PM - Last modified Jan. 2, 2023 3:04 PM